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Cold Sores (Herpes Labialis) The recommended dosage of VALTREX for the treatment of cold sores in pediatric patients aged greater than or equal to 12 years is 2 grams twice daily for 1 day taken 12 hours apart. I felt a tingle and a bump the other day, took it and it has helped tremendously Can you get rid of a cold sore overnight? Valtrex has an average rating of 9. Please, if you suffer from these painful, embarrassing cold sores, try to get a prescription. However, it is important to remember that Valtrex will not cure your herpes infection completely Valtrex Valtrex (Valacyclovir) is also approved by the FDA to treat cold sores and it's a well-known, popular treatment. Take by mouth, such as acyclovir, valacyclovir, or famciclovir. Filter by condition Valtrex rating summary 9. Valtrex works by preventing the herpes virus from growing and spreading. Valtrex is also called valacyclovir hydrochloride. You cannot get rid of cold sores overnight. 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