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Acyclovir (Zovirax) is effective, and its patent expired years ago, so its cost is usually low Nine out of 10 prescriptions filled in the U. A generic drug is a “bioequivalent” – a chemical copy – of the original brand-name medication Difference between Generic Valtrex vs. According to the Congressional Budget Office, generic drugs save consumers approximately 8-10 billion dollars per year at retail pharmacies [6] So what is the difference between brand name and generic drugs? Valtrex was first manufactured by GlaxoSmithKline and the patent expired in December 2009 Comparing Valacyclovir vs Valtrex Valacyclovir Valtrex (valacyclovir) Prescription only Valacyclovir is an antiviral prodrug that is rapidly converted into acyclovir in the body. Brand-name Valtrex medicine - PowerPoint PPT Presentation Actions Remove this presentation Flag as Inappropriate I Don't Like This I like this Remember as a Favorite. In fact, generic drugs cost 85 percent less than the brand version on average. 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